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KMID : 1123920070210040921
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Korean Journal of Oriental Physiology and Pathology
2007 Volume.21 No. 4 p.921 ~ p.933
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Effect of KwyBiChongMung-Tang Hot Water Extract & Ultra-fine Powder on the Alzheimer’s Disease Model
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Lee Sung-Hee
Lee Sang-Ryong
Jung In-Chul
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Abstract
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This experiment was designed to investigate the effects of the KBCMT hot water extract & ultra-fine powder on Alzheimer’s Disease Model Induced by . The effects of the KBCMT hot water extract on expression of , IL-6, , NOS-II, COX-2 mRNA and production of , IL-6, , NO in BV2 microglial cell line treated by lipopolysacchaide(LPS). The effects of the KBCMT hot water extract & ultra-fine powder on (1) the behavior (2) expression of , , MDA, CD68 and CD11b; (3) AChE in serum (4) the infarction area of the hippocampus, and brain tissue injury in Alzheimer’s diseased mice induced with were investigated. The KBCMT hot water extract suppressed the expression of , IL-6 and mRNA in BV2 microglia cell line treated with LPS. The KBCMT hot water extract suppressed the production of , IL-6, , NO in BV2 microglial cell line treated with LPS. The KBCMT hot water extract & ultra-fine powder a significant inhibitory effect on the memory deficit was shown for the mice with Alzheimer’s disease induced by in the Morris water maze experiment, which measured stop-through latency and distance movemet-through latency The KBCMT ultra-fine powder suppressed the expression of TNF-a protein significantly in the microglial cell of mice with Alzheimer’s disease induced by . The KBCMT hot water extract & ultra-fine powder reduced the MDA and suppressed the over-expression of CD68, CD11b in the mice with Alzheimer’s disease induced by . The KBCMT hot water extract & ultra-fine powder decreased AChE significantly in the serum of the mice with Alzheimer’s disease induced by . The KBCMT hot water extract & ultra-fine powder reduced infarction area of hippocampus, and controlled the injury of brain tissue in the mice with Alzheimer’s disease induced by . The KBCMT hot water extract & ultra-fine powder reduced the tau protein, GFAP, and presenilin1, 2 of hippocampus in the mice with Alzheimer’s disease induced by . These results suggest that the KBCMT hot water extract & ultra-fine powder may be effective for the prevention and treatment of Alzheimer’s disease. Investigation into the clinical use of the KBCMT hot water extract & ultra-fine powder for Alzheimer’s disease is suggested for future research.
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KEYWORD
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Alzheimer’s disease, KwyBiChongMung-Tang, hot water extract & ultra-fine powder
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